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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often characterized by their focus on practical aspects of design, including recruitment and consent, adherence and the use of standard equipment.

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Pragmatic is a software company that offers a broad range of casino games for online gambling platforms. Pragmatic's iGaming solutions are utilized by the leading operators and casinos with a physical location. The company provides front-end site design tools, analysis tools and marketing, promotions, security payment systems, customer support, and bug reporting. The company also provides security, high-quality graphics, games and security.

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A practical trial that employs different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for a pragmatic trial to be reliable and reduce bias in results is also essential. However, too much heterogeneity can cause problems with the design of the trial.

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Pragmatic Play has earned a reputation for providing top-quality games and an outstanding user experience. The software is available on mobile devices and in multiple languages. Despite its infancy it has already established itself as a premier gaming platform for casinos. Wolves is one of its latest releases that is a 5-reel slot machine that has a high RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to replicate real-life scenarios and to achieve the highest level of validity externally. They are usually requested by practitioners and policy makers to guide their decision-making. They can be used to determine the causality of an intervention and its results. However, they shouldn't be used as a substitute for explanatory studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which support the validity of a physiological or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the elements of a practical study that includes recruitment, design, delivery of the intervention, and follow-up.

There is a growing increase in the number pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs), yielded 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatic thinking. It is important to keep in mind, however, that the majority of these studies were conducted in primary-care settings.